术前系统性炎症反应指数-预后营养指数评分对结肠癌根治术后患者预后的影响
Effect of systemic immune inflammation index-prognostic nutritional index score on the prognosis of patients with colon cancer after radical surgery
任莹 1蒋文婷 1刘苏雅 1高超2
作者信息
- 1. 徐州医科大学第一临床医学院,江苏 徐州 221004
- 2. 徐州医科大学附属医院肿瘤内科,江苏 徐州 221002
- 折叠
摘要
目的 评价系统性炎症反应指数(SII)-预后营养指数(PNI)评分对结肠癌根治术后患者预后的预测价值.方法 选择 2015 年 1 月—2016 年 12 月徐州医科大学附属医院收治的 144 例结肠癌根治术后患者,收集临床资料,进行回顾性分析.采用受试者工作特征(ROC)曲线确定SII和PNI的最佳截断值,并根据截断值将SII-PIN评分赋值对患者进行分组,分析不同分组与结肠癌根治术后患者临床病理特征及预后的关系.结果 SII与PNI的ROC曲线下面积分别为 0.695、0.754,最佳截断值分别为 658、48.95.根据最佳截断值,SII-PNI评分分组为:SII＜658 且PNI＞48.95 为 0 分(61 例);SII≥658 或PNI≤48.95 为 1 分(41 例);SII≥658 且 PNI≤48.95 为 2 分(42 例).COX多因素回归分析显示,肿瘤的分化程度、浸润程度、TNM分期及SII-PNI评分是影响结肠癌患者无病生存期(DFS)的独立危险因素(P＜0.05),肿瘤的分化程度、TNM分期及SII-PNI评分 2 分是影响结肠癌患者总生存期(OS)的独立危险因素(P＜0.05).生存曲线显示,SII-PNI评分 0 分组的生存率显著高于1 分组和 2 分组(P＜0.05).结论 术前SII-PNI评分是影响结肠癌患者预后的独立危险因素,可用于结肠癌根治术后患者预后评估,评分越高,预后越差.
Abstract
Objective To evaluate the predictive value of the systemic immune inflammatory index(SII)-prog-nostic nutritional index(PNI)score for the prognosis of patients with colon cancer after radical surgery.Methods A ret-rospective analysis was conducted using clinical data from 144 patients with colon cancer who underwent radical surgery in the Affiliated Hospital of Xuzhou Medical University from January 2015 to December 2016.The optimal cutoff values for SII and PNI were determined using the receiver operating characteristic(ROC)curve.The patients were grouped based on the cutoff values and assigned SII-PIN score.The relationships between different groupings and the clinicopathological characteristics and prognosis of patients with colon cancer after radical surgery were analyzed.Results The area under the ROC curves of SII and PNI was 0.695 and 0.754,respectively,with the optimal cutoff values of 658 and 48.95.Ac-cording to the cutoff values,the SII-PNI score was divided as follows:SII＜658 and PNI＞48.95 were 0 point(61 ca-ses);SII≥658 or PNI≤48.95 was 1 point(41 cases);SII≥658 and PNI≤48.95 were 2 points(42 cases).COX multivariate regression analysis showed that the degree of tumor differentiation,infiltration,TNM stage,and SII-PNI score were the independent risk factors affecting DFS in colon cancer patients(P＜0.05),while the degree of tumor differentiation,TNM stage,and SII-PNI score(2 points)were the independent risk factors affecting OS in colon cancer patients(P＜0.05).The survival curve showed that the survival rate of group 0 point with SII-PNI score was significantly higher than those of group 1 point and group 2 points(P＜0.05).Conclusions The preoperative SII-PNI score is an in-dependent risk factor affecting patients with colon cancer,and can be used to evaluate the prognosis of patients after radi-cal resection of colon cancer.
关键词
结肠癌/系统性炎症反应指数-预后营养指数评分/预后/根治术/危险因素Key words
colon cancer/systemic immune inflammatory index-prognosis nutritional index score/prognosis/radi-cal surgery/risk factor引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据