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镇痛药物研发的潜在方向

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生理状态下,疼痛是一种保护性反应,可使机体免受更严重的伤害,有利于物种生存.病理状态下,疼痛作为一种常见的疾病/症状,严重影响患者的生活质量.近年来,疼痛机制研究与镇痛药物研发取得了重要进展,但仍存在许多问题和挑战.本研究旨在系统性梳理该领域的历史经验,展望未来发展方向,以期将疼痛机制研究和镇痛药物研发工作推向更高层次.
Potential directions for the development of anesthetic agents
Pain is a protective response in physiological states,which protects the body from further harm and facili-tates species survival.However,in pathological states,pain becomes a common disease/symptom significantly affecting the quality of life in patients.Recent years have seen great progress in understanding of pain mechanisms and the devel-opment of anesthetic agents,but a number of questions and challenges still remain.The current article is aimed to sys-tematically summarize the historical experience in this field and look forward to the future,in order to push the studies concerning pain mechanisms and the development of anesthetic agents to a much higher level.

painanestheticnon-opioid analgesiapain resiliencecomorbidityartificial intelligencetraditional medicine

葛婷、张红星

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江苏省麻醉学重点实验室,江苏徐州 221004

江苏省麻醉与镇痛应用技术重点实验室,江苏徐州 221004

国家药品监督管理局麻醉精神药物研究与评价重点实验室,江苏徐州 221004

疼痛 镇痛 非阿片类镇痛 疼痛非易感 共病 人工智能 传统医学

国家自然科学基金国家自然科学基金江苏省科技计划专项重点研发计划社会发展项目江苏省双创团队项目江苏省研究生科研与实践创新计划

3197093782271255BE2023690KYCX23_2998

2024

徐州医科大学学报
徐州医学院

徐州医科大学学报

CSTPCD
影响因子:0.395
ISSN:2096-3882
年,卷(期):2024.44(2)
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