Research progress on the role of ferroptosis in regulating pulmonary fibrosis
Pulmonary fibrosis is an interstitial pneumonia,characterized by progressive respiratory difficulty.Due to limited current therapeutic options,patients may finally die of respiratory failure.The mechanisms underlying the development of pulmonary fibrosis are not fully understood.Ferroptosis is a non-apoptotic,iron-dependent form of cell death.In this paper,we explores the potential mechanisms by which ferroptosis regulates pulmonary fibrosis,from the perspectives of glutathione peroxidase 4(GPX4)and ferroptosis-suppressing protein(FSP1),reactive oxygen species(ROS),aging,and endoplasmic reticulum stress,in order to provide more research targets and directions for treatment.
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