蛋白质组学和代谢组学在间质性肺疾病研究中的应用
Application of proteomics and metabolomics of interstitial lung disease research
奚斌 1孟晓 1张露 1刘文文 1陈碧1
作者信息
- 1. 徐州医科大学附属医院呼吸与危重症医学科,江苏 徐州 221002
- 折叠
摘要
间质性肺疾病是一类异质性疾病,以炎症浸润、纤维化、细胞增殖等病理变化累及肺间质为共同特征.该病的临床病因目前尚未完全明确,尤其是在急性加重期,患者的预后往往较差.蛋白质组学和代谢组学联合使用,有希望成为筛选间质性肺疾病新型生物标志物的有力工具.本文综述了蛋白质组学和代谢组学技术在间质性肺疾病研究中的应用,以期明确当前的研究现状,并对未来的研究方向进行展望.
Abstract
Interstitial lung diseases are a heterogeneous group of diseases that share the common features of pathological changes such as inflammatory infiltration,fibrosis,and cell proliferation involving the interstitium of the lungs.The clinical etiology of the disease is not yet fully understood,especially during acute exacerbation,and the prognosis of patients tends to be poor.The combined use of proteomics and metabolomics holds promise as a powerful tool for screening novel biomarkers for interstitial lung diseases.In this paper,we review the application of proteomics and metabolomics techniques in interstitial lung disease research,in order to clarify the current status of research and provide an outlook on future research directions.
关键词
间质性肺疾病/蛋白质组学/代谢组学/疾病生物标志物/发病机制/代谢途径Key words
interstitial lung disease/proteomics/metabolomics/disease biomarkers/pathogenesis/metabolic pathways引用本文复制引用
基金项目
徐州市医学重点人才项目(XWRCHT20220063)
江苏省高校重点实验室开放课题(XZSYSKF2022004)
出版年
2024
NETL
NSTL
万方数据