Clinical study on the expression of Gal-1 and Gal-9 in the serum and placenta of patients with preeclampsia
Objective To investigate the levels of galectin 1(Gal-1)and galectin 9(Gal-9)in the serum and placenta of patients with preeclampsia and their clinical significance.Methods A total of 30 pregnant women with early-onset preeclampsia who were admitted to Northern Jiangsu People's Hospital from November 2022 to August 2023 were selected as an early-onset preeclampsia group.Meanwhile,50 pregnant women with late-onset preeclampsia were selected as a late-onset preeclampsia group.Also,40 healthy pregnant women who had obstetric checkups in our hospital during the same period were selected as a control group.The levels of serum Gal-1 and Gal-9 in each group were detected by enzyme-linked immunosorbent assay.Immunohistochemistry was used to detect the positive expression rate of placental Gal-1 and Gal-9 in each group.Results The early-onset PE group and the late-onset PE group showed higher serum Gal-1 and Gal-9 levels than the control group(P＜0.05),where increased Gal-1 and Gal-9 levels were seen in the early-onset PE group,compared with those in the late-onset PE group(P＜0.05).The early-onset PE group and late-onset PE group showed higher placental Gal-1 and Gal-9 positive expression rates than the control group(P＜0.05),where increased placental Gal-1 and Gal-9 positive expressian rates were seen in the early-onset PE group,compared with those in the late-onset PE group(P＜0.05).Conclusions The levels of Gal-1 and Gal-9 in the serum and placenta of pregnant women with preeclampsia significantly increase,where the early-onset preeclampsia group showed higher levels of Gal-1 and Gal-9 than the late-onset group.These findings suggest that they may be jointly involved in the pathological process of preeclampsia.
preeclampsiahypertension disorders of pregnancyserumplacentagalectin 1galectin 9
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