Gal-1和Gal-9在子痫前期患者血清和胎盘表达的临床研究
Clinical study on the expression of Gal-1 and Gal-9 in the serum and placenta of patients with preeclampsia
赵囡囡 1孔祥 2唐卉 1傅丹2
作者信息
- 1. 扬州大学医学院仪征市人民医院临床学院,江苏仪征 211400;江苏省苏北人民医院妇产科,江苏扬州 225001
- 2. 江苏省苏北人民医院妇产科,江苏扬州 225001
- 折叠
摘要
目的 探讨子痫前期孕妇血清及胎盘中半乳糖凝集素1(Gal-1)和半乳糖凝集素9(Gal-9)的表达水平及其临床意义.方法 选取2022年11月 2023年8月于江苏省苏北人民医院就诊的早发型子痫前期孕妇30例,为早发型PE组;晚发型子痫前期孕妇50例,为晚发型PE组;另择同期在本院产检的健康孕妇40例,为对照组.采用酶联免疫吸附法检测各组血清Gal-1和Gal-9的表达水平.采用免疫组化法检测各组胎盘Gal-1和Gal-9阳性表达率.结果 早发型PE组和晚发型PE组血清Gal-1水平和Gal-9水平显著高于对照组(P＜0.05),且早发型PE组Gal-1水平和Gal-9水平亦显著高于晚发型PE组(P＜0.05).早发型PE组和晚发型PE组胎盘Gal-1和Gal-9阳性表达率显著高于对照组(P＜0.05),且早发型PE组胎盘Gal-1和Gal-9阳性表达率显著高于晚发型PE组(P＜0.05).结论 子痫前期孕妇血清和胎盘中Gal-1和Gal-9表达水平明显升高,且早发型PE组Gal-1和Gal-9水平均高于晚发型PE组,提示二者可能共同参与子痫前期的病理过程.
Abstract
Objective To investigate the levels of galectin 1(Gal-1)and galectin 9(Gal-9)in the serum and placenta of patients with preeclampsia and their clinical significance.Methods A total of 30 pregnant women with early-onset preeclampsia who were admitted to Northern Jiangsu People's Hospital from November 2022 to August 2023 were selected as an early-onset preeclampsia group.Meanwhile,50 pregnant women with late-onset preeclampsia were selected as a late-onset preeclampsia group.Also,40 healthy pregnant women who had obstetric checkups in our hospital during the same period were selected as a control group.The levels of serum Gal-1 and Gal-9 in each group were detected by enzyme-linked immunosorbent assay.Immunohistochemistry was used to detect the positive expression rate of placental Gal-1 and Gal-9 in each group.Results The early-onset PE group and the late-onset PE group showed higher serum Gal-1 and Gal-9 levels than the control group(P＜0.05),where increased Gal-1 and Gal-9 levels were seen in the early-onset PE group,compared with those in the late-onset PE group(P＜0.05).The early-onset PE group and late-onset PE group showed higher placental Gal-1 and Gal-9 positive expression rates than the control group(P＜0.05),where increased placental Gal-1 and Gal-9 positive expressian rates were seen in the early-onset PE group,compared with those in the late-onset PE group(P＜0.05).Conclusions The levels of Gal-1 and Gal-9 in the serum and placenta of pregnant women with preeclampsia significantly increase,where the early-onset preeclampsia group showed higher levels of Gal-1 and Gal-9 than the late-onset group.These findings suggest that they may be jointly involved in the pathological process of preeclampsia.
关键词
子痫前期/妊娠期高血压疾病/血清/胎盘/半乳糖凝集素1/半乳糖凝集素9Key words
preeclampsia/hypertension disorders of pregnancy/serum/placenta/galectin 1/galectin 9引用本文复制引用
基金项目
扬州市科委重点研发(社会发展)项目(YZ2017069)
出版年
2024
NETL
NSTL
万方数据