Research progress on ketamine and its dextroisomer in improving perioperative sleep disorders
Perioperative sleep disorders can present as obstructive sleep apnea,insufficient total sleep time,in-creased nighttime awakenings,and circadian rhythm disturbances,which have profoundly negative effects on disease prognosis.There is an urgent need for more effective preventive and therapeutic strategies.As an N-methyl-D-aspartate(NMDA)receptor antagonist,ketamine and its dextroisomer(esketamine)are widely recognized for their antidepres-sant,sedative,and analgesic effects.Recent studies have confirmed their regulatory effects on sleep cycles and circadian rhythms,significantly improving sleep quality.These effects may be related to their antidepressant,anti-inflammatory,analgesic properties,and regulation of circadian clock genes.
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