氯胺酮及其右旋异构体改善围术期睡眠障碍的研究进展
Research progress on ketamine and its dextroisomer in improving perioperative sleep disorders
马育蕾 1范美含 1任奥林 1王敏 1朱敏敏1
作者信息
- 1. 南京医科大学附属无锡市第二人民医院,江苏 无锡 214400
- 折叠
摘要
围术期睡眠障碍可表现为阻塞性睡眠呼吸暂停、睡眠总时间不足、夜间觉醒增加、昼夜节律紊乱等,对疾病的预后产生极大的负面影响,亟需寻找更优化的预防及治疗措施.氯胺酮及其右旋异构体(艾司氯胺酮)作为N-甲基-D-天冬氨酸(NMDA)受体拮抗剂,在抗抑郁、镇静、镇痛方面的作用已被广泛熟知.近年来,其对睡眠周期及昼夜节律的调节作用也被证实,氯胺酮显著改善睡眠质量可能与抗抑郁、抗炎镇痛及对生物钟基因的调控等作用相关.
Abstract
Perioperative sleep disorders can present as obstructive sleep apnea,insufficient total sleep time,in-creased nighttime awakenings,and circadian rhythm disturbances,which have profoundly negative effects on disease prognosis.There is an urgent need for more effective preventive and therapeutic strategies.As an N-methyl-D-aspartate(NMDA)receptor antagonist,ketamine and its dextroisomer(esketamine)are widely recognized for their antidepres-sant,sedative,and analgesic effects.Recent studies have confirmed their regulatory effects on sleep cycles and circadian rhythms,significantly improving sleep quality.These effects may be related to their antidepressant,anti-inflammatory,analgesic properties,and regulation of circadian clock genes.
关键词
氯胺酮/艾司氯胺酮/围术期/睡眠障碍/慢波睡眠/昼夜节律Key words
ketamine/esketamine/perioperative period/sleep disorders/slow-wave sleep/circadian rhythm引用本文复制引用
出版年
2024
NETL
NSTL
万方数据