Objective Ribosomal protein L5(RPL5)is a member of the ribosomal protein(RP)family.However,the role of RPL5 in tumourigenesis,progression and immunotherapy has not been fully elucidated.Methods The expression of RPL5 in pan-cancer and its correlation with prognosis,immune cell invasion,immunomodulatory genes,tumor mutational burden(TMB)and microsatellite instability(MSI)in cancer patients were analyzed through multiple databases.Results Compared with normal tissues,RPL5 was upregulated in colon adenocarcinoma,glioblastoma multiforme,renal clear cell carcinoma,lung adenocarcinoma,lung squamous cell carcinoma,and hepatocellular carcinoma at both mRNA expression and protein levels.And RPL5 as a significant prognostic risk factor for adrenocortical carcinoma,renal papillary cell carcinoma,and hepatocellular carcinoma.Furthermore,in certain cancers,there was an inverse correlation between RPL5 expression and immune cell infiltration,immunomodulatory genes,TMB,and MSI.Conclusion RPL5 could serve as a prognostic biomarker and potential immunotherapy target of cancer.
Ribosomal protein L5Pan-cancerPrognosisImmune microenvironment
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NSTL
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