Objective To analyze the influencing factors of pulmonary inflammation in patients infected with severe acute respiratory syndreme coronavirus 2(SARS-CoV-2)and the preventive effect of different enhanced immunization with SARS-CoV-2 vaccine,so as to provide scientific basis for the prevention and control of respiratory virus epidemic situation such as SARS-CoV-2.Methods Based on the sociodemographic characteristics,vaccination history,laboratory and imaging examination data of SARS-CoV-2 infected patients admitted to a designated hospital in a city from August to December 2022,the differences of pulmonary inflammation among SARS-CoV-2 infected patients with different characteristics were compared.According to the results of single factor analysis,binary logistic regression model was used to analyze the influencing factors of pulmonary inflammation in patients infected with SARS-CoV-2.Results The average age of 326 SARS-CoV-2 infected persons was(49.1±1.6)years old,84(25.8%)of them had basic diseases,68(20.9%)of them had pulmonary inflammation,180(55.2%)of them had homologous booster immunization,and 146(44.8%)had heterologous booster immunization.Multifactor logistic regression analysis showed that heterologous booster immunization was the protective factor for pulmonary inflammation in SARS-CoV-2 infected persons,and its OR(95%CI)was 0.18(0.17,0.80).In addition,age,obesity and concomitant underlying diseases were risk factors for pulmonary inflammation in patients with SARS-CoV-2 infection,with OR(95%CI)of 1.06(1.03,1.09),3.38(1.29,8.84)and 3.46(1.76,6.80),respectively.Conclusion Heterologous booster immunization,increasing age,obesity and the presence of underlying diseases are the influencing factors of pulmonary inflammation in patients with SARS-CoV-2 infection.Therefore,it is necessary to strengthen the vaccination of SARS-CoV-2 vaccine for the elderly,obese and people with underlying diseases,and carry out heterologous enhanced immunization for such high-risk groups.
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