Objective To analyze the distribution characteristics and drug resistance of pathogenic microorganisms in patients co-infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and other infection,so as to provide evidence for clinical treatment.Methods The clinical data of 637 patients with corona virus disease 2019(COVID-19)infection admitted to the Affiliated Hospital of Yan'an University from December 2022 to February 2023 were collected,and their clinical characteristics and co-infection of pathogenic microorganisms were analyzed retrospectively.Results The patients were mainly elderly,with 79.59%of patients complicated with underlying diseases,and 91.05%of patients improved and recovered.The most common types of culture positive specimens were respiratory tract,blood and urine,with infections mainly caused by Klebsiella pneumoniae,coagulase negative staphylococci(CNS)and fungi,respectively.The drug sensitivity test results showed that Klebsiella pneumoniae had a low resistance rate to β-lactam and the third and fourth generations of cephalosporins(14%～20%).Acinetobacter baumannii was more resistant to aminoglycosides and β-lactam compounds(both>45%),and the resistance rate of Escherichia coli to β-lactam and its compounds was low(14%～19%).Staphylococcus aureus,CNS,Enterococcus faecium and Enterococcus faecalis were not found to be resistant to vancomycin,linezolid and tigacycline.Conclusion The pathogens of COVID 19 co-infection were mainly Gram-negative bacteria and fungi,and the infection site was mainly respiratory tract,and the main pathogen was Klebsiella pneumoniae.The resistance rate of Acinetobacter baumannii to aminoglycosides and β-lactam compounds was higher than the national average level of bacterial drug resistance.It is suggested that in clinical practice,appropriate therapeutic drugs should be selected based on the microbial identification and drug sensitivity test results of COVID-19 patients,in order to improve their prognosis.
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