Evaluation of the therapeutic effect of different concentrations of tranexamic acid solution in the treatment of female melasma based on Zishui Hanmu method
Objective To observe the efficacy and safety of Qihuang oral liquid under the guidance of"Zishui Hanmu method"in the treatment of melasma with different concentrations of tranexamic acid solution.Methods A total of 120 volunteers with melasma were selected from the dermatology clinic of the Second Affiliated Hospital of Henan University of Science and Technology from January 2021 to December 2022.They were randomly divided into three groups with 40 cases in each group.Group C took vitamin C tablets,vitamin E softgel,Qihuang oral liquid;Group B was given 5%tranexamic acid solution on the basis of group C,twice a month;Group A was given 10%tranexamic acid solution on the basis of group C,twice a month.The treatment course of the three groups was 3 months and melasma area severity index(MASI),skin image detection score,oxidative stress index[maleic dialdehyde(MDA),glutathione peroxidase(GSH-Px)and superoxide dismutase(superoxide dismutase,SOD)levels were measured.Results The effective rate was 87.5%in group A,67.5%in group B and 52.5%in group C,and the difference was statistically significant(P<0.05).After treatment,MASI scores,skin image detection scores and MDA scores were all decreased,while GSH-Px and SOD scores were increased(P<0.05).Inter group comparison,group A was superior to group B and group B was superior to group C(P<0.05).Conclusion Both high or low concentration tranexamic acid solution group and Qihuang oral liquid group could treat melasma.However,the introduction of 10%tranexamic acid solution group can more effectively treat melasma,increase GSH-Px and SOD,reduce MDA,and improve MASI.In skin image detection,visible spots,ultraviolet spots,and red areas can be improved with high safety.
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