A study of the correlation between renal function and left ventricular structure and function
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NETL
NSTL
万方数据
目的 本研究旨在探讨使用胱抑素C(cystatin C,CysC)估算肾小球滤过率(estimated glomerular filtration rate based on cystatin C,eGFR-CysC)确定的肾功能与心脏磁共振(cardiovascular magnetic resonance,CMR)成像评估的左心室(left ventricular,LV)结构及功能之间的关系.方法 从英国生物银行(UK Biobank,UKB)数据库中筛选具有eGFR-CysC和CMR数据的一般人群,使用多元线性回归模型探讨肾功能与心脏表型之间的关联.结果 共筛选35 847名UKB参与者,eGFR每降低一个标准差(14.21 mL/min/1.73 m2),LV容积变小(舒张末期容积,β=1.359;收缩末期容积,β=0.492),LV搏出量减少(β=0.889),LV质量降低(β=0.639),LV同心度增加(β=-0.002),LV收缩功能受损(β=0.108,P均<0.05).结论 肾功能降低与不良心脏表型之间存在明显关联,独立于心脏代谢疾病等因素.早期积极干预可能有助于预防不良心脏重塑的进展.
Objective To investigate the relationship between renal function,as determined by estimated glomerular filtration rate based on cystatin C(eGFR-CysC),and left ventricular(LV)structure and function,as assessed through cardiac magnetic resonance(CMR)imaging.Methods The participants from the UK Biobank with available eGFR-CysC and CMR data were selected to explore the association between renal function and cardiac phenotypes using multiple linear regression.Results 35 847 UK Biobank participants were included,and observed that for each standard deviation decrease in eGFR(equivalent to 14.21 mL/min/1.73 m2).There were statistically significant associations with smaller LV volumes(end-diastolic volume,β= 1.359;end-systolic volume,β=0.492),reduced LV stroke volume(β=0.889),lower LV mass(β=0.639),increased LV concentricity(β=-0.002),and impaired LV systolic function(β=0.108,all P<0.05).Conclusion Our findings demonstrate a significant association between decreased renal function and adverse cardiac phenotypes,independently of factors such as cardiometabolic disease.Early and aggressive interventions may play a crucial role in preventing the progression of adverse cardiac remodeling.
NETL
NSTL
万方数据
