Objective Utilizing a two-way two-sample Mendelian randomization(MR)approach,this study aims to investigate the causal relationship between oral ulcers and breast cancer.Methods Employing data from a large-scale genetic dataset,a bidirectional MR analysis was conducted using an exposure dataset and an outcome dataset to infer causal relationships.Genetic instruments associated with oral ulcers were identified,and their association with breast cancer was examined.To ensure the robustness of causal inference,multiple MR methods,including MR egger,inverse variance weighting(IVW),weighted median(WM),simple mode,and weighted mode,were employed.Additionally,heterogeneity and multidirectionality tests were performed to assess the reliability of MR results.Results The MR analysis revealed a suggestive negative association between oral ulcers and breast cancer when oral ulcers were considered as an exposure factor(OR 0.396;95%CI 0.175 to 0.897;P<0.05).No significant results supporting the effect of breast cancer on oral ulcers were observed in the inverse MR(all P>0.05).Conclusion Using MR methods,it was demonstrated that oral ulcers may serve as a protective factor against breast cancer,emphasizing the importance of integrating various methodologies in exploring the relationship between oral ulcers and breast cancer.
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