Objective To investigate the safety and clinical effects of non-Descemet stripping deep anterior lamellar keratoplasty for keratoconus.Methods A total of 6 patients(6 eyes)of keratoconus who were hospitalized in Xi'an No.1 Hospital from January 2018 to January 2020 were collected;all of them underwent non-Descemet stripping deep anterior lamellar keratoplasty.Postoperative follow-up was performed for 12 to 24 months,and postoperative visual acuity,graft transparency and adhesion,and changes in central corneal thickness were observed.Results During the follow-up period,the corneal grafts of all patients were transparent,and the grafts adhered closely to the implant bed.The visual acuity of 6 patients was significantly improved than that before the operation.The central corneal thickness of 6 patients was higher than normal in the early postoperative period.Among them,2 cases were higher than 600 μm and 4 cases were higher than 570 μm.The corneal thickness gradually decreased after the operation,and there was no significant change after 3 months.Conclusion Non-Descemet stripping deep anterior lamellar keratoplasty for keratoconus is safety and effective.