Objective To analyze the therapeutic effect of Jianpi Yifei Xiaoji Decoction combined with navelbine plus Cisplatin (NP) chemotherapy regimen on patients with Non-small cell lung cancer (NSCLC). Methods 138 NSCLC patients admitted to Puyang Traditional Chinese Medicine Hospital from April 2021 to May 2023 were selected as the research subjects. According to the treatment plan,the patients were divided into a control group and an observation group,with 69 cases in each group. The control group was treated with NP chemotherapy regimen,while the observation group was treated with Jianpi Yifei Xiaoji Decoction in addition to the control group. The clinical efficacy,toxic side effects,Karnofsky (KPS) scores before and after treatment,and immune function indicators (CD3+、CD4+、CD8+、CD4+/CD8+T lymphocyte),serum marker levels including carbohydrate antigen 125 (CA125),carcinoembryonic antigen (CEA),CC chemokine ligand 25 (CCL25),and latent transforming growth factor beta binding protein-2 (LTBP2) were compared.Results After treatment,the total effective rate,the KPS and the immune function idicators levels of CD3+、CD4+、CD4+/CD8+T lymphocyte of the observation group was higher than that of the control group,with statistically significant difference (P<0.05). After treatment,the levels of CD8+T lymphocyte,and serum marker levels of CA125,CEA,CCL25,and LTBP2 in the observation group were lower than those in the control group,with statistically significant difference (P<0.05);The incidence of thrombocytopenia,bone marrow suppression,leukopenia,vomiting,nausea,and liver function damage in the observation group were lower than those in the control group (P<0.05).Conclusion The combination of Jianpi Yifei Xiaoji Decoction and NP chemotherapy regimen can improve the anti-tumor effect,enhance immune function,reduce the incidence of toxic side effects,and improve the functional status of NSCLC.
Jianpi Yifei Xiaoji DecoctionNP chemotherapyNon-small cell lung cancerToxic side effects
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