Objective To explore the relationship between inflammation and the development of diabetes retinopathy by detecting the levels of interleukin-6 (IL-6),tumor necrosis factor-a (TNF-α),vascular endothelial growth factor (VEGF),tissue factor (TF) and tissue factor pathway inhibitor (TFPI) in the peripheral serum of rats with diabetes retinopathy. Methods Twenty SD rats were induced by streptozocin (STZ) to establish the model of diabetes. Nine rats with diabetes retinopathy were taken as the experimental group,and 11 rats without diabetes retinopathy were taken as the control group. The changes in related factors in the fundus and serum of two groups were observed. a retinal imaging system was used to perform fundus color photography and fundus fluorescein angiography (FFA) on the experimental group and control group to observe changes in different cycles. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of IL-6,TNF-α,VEGF,TF,and TFPI in rat serum,and statistical analysis was performed. Results The experimental group showed white flocculent phenomena in the area far away from the optic disc after one month and around the optic disc after two months of fundus color photography,while the control group showed normal symptoms. FFA imaging showed dot like and cotton like fluorescence accumulation and leakage in the fundus of the experimental group after one month;Two months later,the experimental group showed extensive fluorescence leakage. And the control group was not observed. There was no statistically significant difference in IL-6 levels between the experimental group and the control group (P>0.05). The levels of TNF-α,VEGF,and TF in the experimental group were higher than those in the control group,but the TFPI level was lower than that in the control group,and the difference was statistically significant (P<0.05). IL-6,TNF-a,VEGF,and TF were all positively correlated,but the correlation between IL-6 and VEGF was not statistically significant (P>0.05),while TNF-α was statistically significant (P<0.05);IL-6,TNF-α,VEGF,and TFPI levels were all negatively correlated,but only the latter two have statistical significance (P<0.05). The AUC in diabetes retinopathy (DR) was TFPI>TF>TNF-α>VEGF>IL-6. Conclusion There is a certain correlation between inflammatory factors and diabetic retinopathy,and inflammation plays a certain role in the pathogenesis and development of diabetic retinopathy,suggesting that the progression of diabetic retinopathy can be prevented and treated by controlling inflammation in clinic.
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