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血浆致动脉粥样硬化指数与高血压合并冠心病的相关性

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[目的]探讨血浆致动脉粥样硬化指数(AIP)与高血压合并冠心病的相关性,旨在为AIP预测高血压合并冠心病患者冠状动脉病变程度提供依据.[方法]选择因原发性高血压合并冠心病行冠状动脉造影术的患者558例,根据检查结果分为高血压未合并冠心病组(151 例)和高血压合并冠心病组(407 例).按照SYNTAX评分标准对冠状动脉病变程度进行评分,再将高血压合并冠心病组分为低危组(230例)、中危组(122例)及高危组(55例).比较各组一般资料、血糖及血脂水平,运用ROC曲线预测高血压合并冠心病患者的AIP值.应用多因素Logistic回归分析影响冠状动脉狭窄程度的独立危险因素,并使用ROC曲线评价AIP对高血压合并冠心病患者冠状动脉狭窄程度的预测价值.[结果]高血压合并冠心病组与高血压未合并冠心病组性别、民族、饮酒、身高、体质量、体质量指数(BMI)及总胆固醇(TC)间差异均无统计学意义(P>0.05),而吸烟、年龄、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、AIP及空腹血糖水平间差异均具有统计学意义(P<0.05).AIP对高血压合并冠心病预测能力的ROC曲线分析结果显示,AIP>2.29 时高血压合并冠心病的风险升高.高血压合并冠心病组中SYNTAX评分与BMI、TG、低密度脂蛋白胆固醇、AIP及空腹血糖水平呈正相关(P<0.05),与年龄及HDL-C水平存在负相关性(P<0.05),低、中及高危组病变支数分布间差异具有统计学意义(P<0.05).多因素Logistic回归分析结果显示,AIP是评估冠状动脉狭窄程度的独立危险因素.AIP与SYNTAX评分的ROC曲线分析结果显示,AIP>2.43 时中危及以上冠状动脉狭窄程度风险升高,AIP>2.66 时高危及以上冠状动脉狭窄程度风险升高.[结论]AIP可为评估高血压合并冠心病患者冠状动脉病变程度提供依据.
Correlation between atherogenic index of plasma and hypertension combined with coronary heart disease
OBJECTIVE To investigate the correlation between atherogenic index of plasma(AIP)and hypertension combined with coronary heart disease(CHD)in order to provide evidence for AIP in predicting the degree of coronary artery disease in patients with hypertension combined with CHD.METHODS A total of 558 patients with primary hypertension combined with CHD were selected for coronary angiography.According to the examination results,the patients were divided into hypertension without CHD group(151 cases)and hypertension with CHD group(407 cases).The degree of coronary artery disease was scored according to SYNTAX scoring standard,and then the hypertension with CHD group was divided into low-risk group(230 cases),medium-risk group(122 cases)and high-risk group(55 cases).General data,blood glucose and blood lipids levels of all groups were compared,and ROC curve was used to predict the AIP value of patients with hypertension combined with CHD.Multivariate Logistic regression was used to analyze the independent risk factors affecting the degree of coronary artery stenosis,and ROC curve was used to evaluate the predictive value of AIP in the degree of coronary artery stenosis in patients with hypertension combined with CHD.RESULTS There were no significant differences in gender,nationality,drinking,height,body mass,body mass index(BMI)and total cholesterol(TC)between hypertension with CHD group and hypertension without CHD group(P>0.05),while there were significant differences in smoking,age,triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),AIP and fasting blood glucose(P<0.05).ROC curve analysis of predictive ability of AIP in predicting hypertension combined with CHD showed that the risk of hypertension combined with CHD increased when AIP>2.29.The SYNTAX score was positively correlated with BMI,TG,low-density lipoprotein cholesterol,AIP and fasting blood glucose in hypertension with CHD group(P<0.05),while was negative correlated with age and HDL-C(P<0.05),and there was statistical significance in the distribution of the number of lesions in low,middle and high-risk groups(P<0.05).Multivariate Logistic regression analysis showed that AIP was an independent risk factor for evaluating the degree of coronary artery stenosis.ROC curve analysis of AIP and SYNTAX scores showed that when AIP>2.43,the risk of medium-risk and above coronary artery stenosis increased,and when AIP>2.66,the risk of high-risk and above coronary artery stenosis increased.CONCLUSION AIP can provide a basis for evaluating the degree of coronary artery disease in patients with hypertension combined with CHD.

coronary heart diseasehypertensionatherogenic index of plasmaSYNTAX score

玲玲、张克男、李传奇、玄春花

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延边大学附属医院 全科医学科,吉林 延吉 133000

冠心病 高血压 血浆致动脉粥样硬化指数 SYNTAX评分

国家自然科学基金

82160062

2024

延边大学医学学报
延边大学

延边大学医学学报

影响因子:0.308
ISSN:1000-1824
年,卷(期):2024.47(1)
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