Correlation between atherogenic index of plasma and hypertension combined with coronary heart disease
OBJECTIVE To investigate the correlation between atherogenic index of plasma(AIP)and hypertension combined with coronary heart disease(CHD)in order to provide evidence for AIP in predicting the degree of coronary artery disease in patients with hypertension combined with CHD.METHODS A total of 558 patients with primary hypertension combined with CHD were selected for coronary angiography.According to the examination results,the patients were divided into hypertension without CHD group(151 cases)and hypertension with CHD group(407 cases).The degree of coronary artery disease was scored according to SYNTAX scoring standard,and then the hypertension with CHD group was divided into low-risk group(230 cases),medium-risk group(122 cases)and high-risk group(55 cases).General data,blood glucose and blood lipids levels of all groups were compared,and ROC curve was used to predict the AIP value of patients with hypertension combined with CHD.Multivariate Logistic regression was used to analyze the independent risk factors affecting the degree of coronary artery stenosis,and ROC curve was used to evaluate the predictive value of AIP in the degree of coronary artery stenosis in patients with hypertension combined with CHD.RESULTS There were no significant differences in gender,nationality,drinking,height,body mass,body mass index(BMI)and total cholesterol(TC)between hypertension with CHD group and hypertension without CHD group(P>0.05),while there were significant differences in smoking,age,triacylglycerol(TG),high density lipoprotein cholesterol(HDL-C),AIP and fasting blood glucose(P<0.05).ROC curve analysis of predictive ability of AIP in predicting hypertension combined with CHD showed that the risk of hypertension combined with CHD increased when AIP>2.29.The SYNTAX score was positively correlated with BMI,TG,low-density lipoprotein cholesterol,AIP and fasting blood glucose in hypertension with CHD group(P<0.05),while was negative correlated with age and HDL-C(P<0.05),and there was statistical significance in the distribution of the number of lesions in low,middle and high-risk groups(P<0.05).Multivariate Logistic regression analysis showed that AIP was an independent risk factor for evaluating the degree of coronary artery stenosis.ROC curve analysis of AIP and SYNTAX scores showed that when AIP>2.43,the risk of medium-risk and above coronary artery stenosis increased,and when AIP>2.66,the risk of high-risk and above coronary artery stenosis increased.CONCLUSION AIP can provide a basis for evaluating the degree of coronary artery disease in patients with hypertension combined with CHD.
coronary heart diseasehypertensionatherogenic index of plasmaSYNTAX score