Predictive value of common inflammatory indicators in septic cardiomyopathy
OBJECTIVE To explore the predictive value of common inflammatory indicators in septic cardiomyopathy,in order to provide evidence for clinical evaluation of septic cardiomyopathy.METHODS A total of 60 patients diagnosed with sepsis in the Affiliated Hospital of Yanbian University from January 2021 to December 2021 were selected as the study objects.An echocardiographic left ventricular ejection fraction(LVEF)<0.50 on the 3rd day of ICU admission was used as the diagnostic criteria for septic cardiomyopathy.The patients were divided into sepsis-induced myocardial dysfunction(SIMD)group and non-SIMD group.The changes of inflammatory indicators on the 1st,3rd and 5th day of admission were compared between the two groups,and the correlation with LVEF(%)was analyzed.Receiver operating characteristic curve(ROC curve)was used to analyze the predictive value of common inflammatory indicators at each time point(the 1st,3rd and 5th day of admission)for septic cardiomyopathy,and the predictive value of various inflammatory indicators combined at each time point for septic cardiomyopathy was analyzed.RESULTS A total of 22(36.6%)of 60 patients with sepsis developed septic cardiomyopathy,the levels of PCT and CRP on day 1,3 and 5,NEUT(%)level on day 1 and WBC level on day 5 of admission in the SIMD group were significantly higher than those in the non-SIMD group(P<0.05).There were no significant differences in PLT,IL-6,LYMPH levels on day 1,day 3 and day 5,NEUT(%)levels on day 3 and day 5 and WBC levels on day 1 and day 3 of admission between the two groups(P>0.05).The levels of PCT and CRP on day 1,3 and 5 and WBC level on day 5 of admission were negatively correlated with LVEF(%)(P<0.05).The ROC curve analysis data for predicting septic cardiomyopathy showed that the area under the curve of CRP on the 1st day of admission was the largest(0.977),the sensitivity and specificity were 1.000 and 0.842,respectively,and the cut-off value was 187.34 mg/L.The area under the curve of PCT combined with CRP on the 1st day of admission was 0.977,and the sensitivity and specificity were 0.955 and 0.895,respectively.CONCLUSION PCT combined with CRP is correlated with the occurrence of septic cardiomyopathy,and can be used to predict the occurrence of septic cardiomyopathy,and is negatively correlated with cardiac function.