首页|常见炎症指标对脓毒症心肌病的预测价值

常见炎症指标对脓毒症心肌病的预测价值

扫码查看
[目的]探讨常见炎症指标对脓毒症心肌病的预测价值,旨在为临床评估脓毒症心肌病提供依据.[方法]选择于2021年1月—2021年12月间在延边大学附属医院诊断为脓毒症的60例患者作为研究对象,以入ICU第3天时的超声心动图左心室射血分数(LVEF)<0.50 作为脓毒症心肌病的诊断标准分为脓毒症心肌抑制(SIMD)组和非SIMD组,比较两组患者入院第1、3、5 天时的炎症指标变化情况,并分析其与 LVEF(%)的相关性;采用受试者工作特征曲线(ROC曲线)分析各时间点(入院第 1、3、5 天)常见炎症指标对脓毒症心肌病的预测价值,同时分析各时间点各项指标联合对脓毒症心肌病的预测价值.[结果]本组60例脓毒症患者中22 例(36.6%)发生脓毒症心肌病,SIMD组入院第 1、3、5 天时的PCT、CRP水平、第 1 天时的NEUT(%)及第 5 天时的WBC水平均明显高于非SIMD组,差异均具有统计学意义(P<0.05);两组入院第1、3、5天时的PLT、IL-6、LYMPH水平、第3、5天时的NEUT(%)水平及第1、3天时的WBC水平间无明显差异(P>0.05).入院第1、3、5天时的PCT、CRP及入院第5天时的WBC水平与LVEF(%)呈负相关(P<0.05).预测脓毒症心肌病的ROC曲线分析结果显示,入院第1天时的CRP曲线下面积最大,为0.977,敏感性和特异性分别为1.000和0.842,截断值为187.34 mg/L.入院第 1 天时的PCT联合CRP曲线下面积为 0.977,敏感性和特异性分别为 0.955 和 0.895.[结论]PCT联合CRP变化与脓毒症心肌病的发生具有相关性,可用于预测脓毒症心肌病的发生,且与心功能呈负相关.
Predictive value of common inflammatory indicators in septic cardiomyopathy
OBJECTIVE To explore the predictive value of common inflammatory indicators in septic cardiomyopathy,in order to provide evidence for clinical evaluation of septic cardiomyopathy.METHODS A total of 60 patients diagnosed with sepsis in the Affiliated Hospital of Yanbian University from January 2021 to December 2021 were selected as the study objects.An echocardiographic left ventricular ejection fraction(LVEF)<0.50 on the 3rd day of ICU admission was used as the diagnostic criteria for septic cardiomyopathy.The patients were divided into sepsis-induced myocardial dysfunction(SIMD)group and non-SIMD group.The changes of inflammatory indicators on the 1st,3rd and 5th day of admission were compared between the two groups,and the correlation with LVEF(%)was analyzed.Receiver operating characteristic curve(ROC curve)was used to analyze the predictive value of common inflammatory indicators at each time point(the 1st,3rd and 5th day of admission)for septic cardiomyopathy,and the predictive value of various inflammatory indicators combined at each time point for septic cardiomyopathy was analyzed.RESULTS A total of 22(36.6%)of 60 patients with sepsis developed septic cardiomyopathy,the levels of PCT and CRP on day 1,3 and 5,NEUT(%)level on day 1 and WBC level on day 5 of admission in the SIMD group were significantly higher than those in the non-SIMD group(P<0.05).There were no significant differences in PLT,IL-6,LYMPH levels on day 1,day 3 and day 5,NEUT(%)levels on day 3 and day 5 and WBC levels on day 1 and day 3 of admission between the two groups(P>0.05).The levels of PCT and CRP on day 1,3 and 5 and WBC level on day 5 of admission were negatively correlated with LVEF(%)(P<0.05).The ROC curve analysis data for predicting septic cardiomyopathy showed that the area under the curve of CRP on the 1st day of admission was the largest(0.977),the sensitivity and specificity were 1.000 and 0.842,respectively,and the cut-off value was 187.34 mg/L.The area under the curve of PCT combined with CRP on the 1st day of admission was 0.977,and the sensitivity and specificity were 0.955 and 0.895,respectively.CONCLUSION PCT combined with CRP is correlated with the occurrence of septic cardiomyopathy,and can be used to predict the occurrence of septic cardiomyopathy,and is negatively correlated with cardiac function.

septic cardiomyopathybiomarkerinflammation

格力巴、崔青松

展开 >

通辽市人民医院,内蒙古 通辽 028000

延边大学附属医院,吉林 延吉 133000

脓毒症心肌病 生物标志物 炎症

吉林省联合基金白求恩医学专项延边大学应用基础项目

20200201413JC延大科合字[2021]16号

2024

延边大学医学学报
延边大学

延边大学医学学报

影响因子:0.308
ISSN:1000-1824
年,卷(期):2024.47(1)
  • 10