Clinical analysis of analgesic effect of intrathecal infusion of hydromorphone hydrochloride on patients with cancer pain
OBJECTIVE To observe the analgesic effect of intrathecal infusion of hydromorphone hydrochloride on patients with cancer pain.METHODS Fifty patients with cancer pain who were treated with morphine sustained-release tablets by oral administration and then changed with intrathecal implantation of hydromorphone hydrochloride pump were selected as the study objects.The pain scores,quality of life,dosage,number of breakthrough pain within 24 hours and the occurrence of adverse reactions such as nausea,vomiting and withdrawal caused by opioids were observed before and after the change of analgesia mode.RESULTS The NRS scores of 50 patients with cancer pain decreased significantly 24 hours after intrathecal implantation of hydromorphone hydrochloride pump(P＜0.05).The quality of life was significantly improved,and the adverse reactions such as nausea and vomiting were significantly alleviated,and withdrawal reaction occurred in 3 cases.There was no correlation between the occurrence of cancer bone metastasis and drug use(P＞0.05).Postoperative drug dosage was significantly decreased in patients with cancer bone metastasis(P＜0.05).There was no correlation between the occurrence of cancer bone metastasis and the number of breakthrough pain(P＞0.05),but the number of breakthrough pain increased before surgery and decreased significantly after surgery in patients with cancer bone metastasis(P＜0.05).CONCLUSION Intrathecal implantation of hydromorphone hydrochloride pump can reduce the pain scores,the dosage,the number of breakthrough pain within 24 hours,the incidence of adverse reactions such as nausea and vomiting,and improve the quality of life and reduce the incidence of withdrawal reactions in patients with cancer pain.
cancer painintrathecal implantation pumphydromorphone hydrochlorideanalgesic effect
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