Correlation of serum glutamyl transpeptidase in the normal range with prehypertension
OBJECTIVE To observe the correlation of serum glutamyl transpeptidase(GGT)level in the normal range with prehypertension.METHODS A total of 4 006 subjects aged 20-60 years without hypertension and with normal liver function who participated in health physical examination from June 2019 to September 2019 were selected as the study subjects.The correlation of GGT levels within the normal range with prehypertension was analyzed between different genders population.RESULTS Compared with the control group,the age,body mass index(BMI),blood glucose(FPG),total cholesterol(TC),low density lipoprotein(LDL),triglyceride(TG),aspartate aminotransferase(AST),alanine aminotransferase(ALT)and GGT levels were significantly increased in the male prehypertension group(P＜0.05).The age,BMI,FPG,TC,LDL,TG,AST,ALT,GGT,uric acid(UA)and creatinine(CREA)in the female prehypertension group were significantly higher(P＜0.05),while the level of high density lipoprotein(HDL)was significantly lower(P＜0.05).Male age,BMI,systolic blood pressure(SBP),diastolic blood pressure(DBP),FPG,TC,LDL,TG,AST,ALT and UA level increased with the increase of GGT level,while HDL level decreased with the increase of GGT level.Female age,BMI,SBP,DBP,FPG,TC,LDL,TG,AST,ALT,UA,blood urea nitrogen and creatinine(CREA)level increased with the increase of GGT level.In males,unadjusted,the risk of prehypertension in the upper quartile of GGT was 1.881 times higher than the lower quartile(95％CI:1.391-2.544),after adjusting for age,BMI,FPG,blood lipid,liver function and other indicators,it was 1.467 times higher than the lower quartile group(95％CI:1.055-2.041).In females,unadjusted,the risk of prehypertension in the upper quartile of GGT was 2.295 times higher than the lower quartile(95％CI:1.791-2.939),however,this relationship disappeared after adjusting for age,BMI,FPG,lipid profile,liver function,and renal function.After adjusting for age,FBG,lipid profile,liver function and other factors,the prevalence rate of prehypertension in individuals with a BMI≥24 kg/m2 and upper quartile of GGT levels was 2.486 times higher(95％CI:1.634-3.783)in males and 2.027 times higher(95％CI:1.387-2.962)in females than those with a BMI＜24 kg/m2 and lower quartile of GGT levels.Additionally,there was an interaction between BMI and GGT in the prevalence of prehypertension in both males and females(Pinteraction＜0.001).CONCLUSION Elevated GGT level within the normal range is a risk factor for prehypertension,particularly in males,and there is an interaction between GGT and BMI in the prevalence of prehypertension.
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