首页|2022-2023年4 747例急性下呼吸道感染儿童呼吸道病原体流行病学特征变化分析

2022-2023年4 747例急性下呼吸道感染儿童呼吸道病原体流行病学特征变化分析

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[目的]分析急性下呼吸道感染(ALRI)住院患儿常见呼吸道病原体的流行病学特征变化,旨在为预防及治疗儿童呼吸道感染提供依据.[方法]选择自2022年1月至2023年12月间在福建省漳州市医院儿科接受住院治疗的4 747例ALRI患儿作为研究对象.采集所有研究对象的咽拭子标本并进行13种呼吸道病原体核酸检测,比较2022年与2023年13种呼吸道病原体的检出率.[结果]13种呼吸道病原体核酸检测结果显示,2023年呼吸道病原体总检出率为63.07%(1 204/1 909),显著高于2022年(59.23%,1 681/2 838;P<0.05);与2022年比较,2023年肺炎支原体(Mp)、甲型流行性感冒病毒(FluA)、H1N1(2009)和呼吸道合胞病毒(RSV)检出率明显升高,而腺病毒、人博卡病毒、H3N2、副流行性感冒病毒、人偏肺病毒、乙型流行性感冒病毒和人鼻病毒检出率明显降低,相比较差异均具有统计学意义(P<0.05).[结论]2022-2023年漳州地区ALRI儿童呼吸道病原体Mp、FluA、H1N1和RSV检出率呈升高趋势,建议针对病原体流行趋势变化加强监测、预防与控制.
Analysis of the epidemiological changes of respiratory pathogens in 4 747 children with acute lower respiratory tract infection from 2022 to 2023
OBJECTIVE Exploring the epidemiological changes of common respiratory pathogens in hospitalized children of acute lower respiratory infection(ALRI),providing a basis for the prevention and treatment of respiratory infections in children.METHODS The participants of the study were 4 747 children hospitalized for ALRI in Zhangzhou Municipal Hospital of Fujian Province from January 2022 to December 2023.Throat swab specimens were collected,and 13 respiratory pathogens were detected using multiplex PCR.The detection rates of 13 respiratory pathogens were collected and analyzed.RESULTS The positive rate of pathogen detection was significantly higher in 2023(63.07%,1 204/1 909)than that in 2022(59.23%,1 681/2 838;P<0.05).The detection rates of Mp,influenza A(FluA),influenza A H1N1 pdm09 virus(H1N1)and respiratory syncytial virus(RSV)in 2023 were higher than that in 2022.In contrast,the detection rates of adenovirus,human bocavirus,influenza A H3N2 virus,parainfluenza virus,human metapneumovirus,influenza B and HRV in 2023 were lower than that in 2022,respectively(P<0.05).CONCLUSIONS The detection rates of respiratory pathogens Mp,FluA,H1N1,and RSV in children with ALRI in Zhangzhou area are showing an upward trend.It is necessary to strengthen monitoring,prevention and control in response to changes in pathogen prevalence trends.

respiratory pathogensepidemiologychildren

蔡梦云、江祎桢、杨燕珍、罗春绸

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福建医科大学附属漳州市医院,福建漳州 363000

呼吸道病原体 流行病学 儿童

福建省自然科学基金联合资金新上项目计划

2023J011812

2024

延边大学医学学报
延边大学

延边大学医学学报

影响因子:0.308
ISSN:1000-1824
年,卷(期):2024.47(2)