Distribution of pathogenic bacteria,changes of myocardial enzymes and inflammatory factors in elderly patients with acute respiratory failure complicated with pulmonary infection
BACKGROUND To investigate the distribution of pathogenic bacteria,myocardial enzymes profile and inflammatory factors in elderly patients with acute respiratory failure complicated with pulmonary infection.CASE REPORTS 120 elderly patients with acute respiratory failure admitted from December 2021 to December 2023 were selected.They were divided into a lung infection group of 39 cases and a non lung infection group of 81 cases based on whether the patients were complicated with lung infection.Analyze the distribution and drug resistance of pathogenic bacteria in the lung infection group;Compare the myocardial enzyme spectrum indicators and inflammatory factor levels between the pulmonary infection group and the non pulmonary infection group;Analyze the correlation between myocardial enzyme spectrum indicators and inflammatory factors in lung infection groups.As a result,50 strains of pathogenic bacteria were cultured in sputum samples from 39 patients with concurrent pulmonary infections,including 10 strains(20.0%)of Gram positive bacteria,36 strains(72.0%)of Gram negative bacteria,and 4 strains(8.0%)of fungi.The serum creatine kinase(CK),lactate dehydrogenase(LDH),creatine kinase isoenzyme(CKMB),procalcitonin(PCT),and C-reactive protein(CRP)in the lung infection group were all higher than those in the non lung infection group(P<0.05).The Pearson correlation analysis results showed that the myocardial enzyme spectrum indicators CK,LDH,CKMB in the lung infection group were positively correlated with inflammatory factors PCT and CRP(P<0.05).DISCUSSION Gram negative bacteria are the main pathogens isolated from elderly patients with acute respiratory failure and pulmonary infection.The serum CK,LDH,CKMB,PCT,and CRP levels of the patients are all highly expressed,and the above indicators can be used as disease monitoring indicators in clinical practice.