Clinical value of serum N-acetylneuramic acid and S100 calc-binding protein A1 levels in predicting prognosis of cases with acute cerebral infarction
OBJECTIVE To explore the clinical efficacy of serum N-acetylneuramic acid(Neu5Ac)and S100 calc-binding protein Al(S100A1)levels in predicting prognosis of cases with acute cerebral infarction(ACI).METHODS Eighty cases with ACI from August 2021 to August 2022 were selected as the study group,and were divided into mild group(n=35),moderate group(n=30)and severe group(n=15).The cases were divided into good prognosis group(n=54)and bad prognosis group(n=26)according to the follow-up 3 months after treatment.Another 70 healthy subjects were selected as control group.The serum levels of Neu5Ac and S100A1 were detected within 24h after admission.ROC was used to evaluate the diagnostic value of serum Neu5Ac and S100A1 in the prognosis of cases with ACI.RESULTS Serum levels of Neu5Ac and S100A1 in study group were higher compared with control group(P＜0.05).Serum levels of Neu5Ac and S100A1 in severe group were higher than those in moderate group and mild group(severe group＞moderate group＞mild group,P＜0.05).Serum levels of Neu5Ac and S100A1 in cases with acute cerebral infarction with poor prognosis were higher than those in good prognosis group(P＜0.05).The AUC of serum Neu5Ac and S100A1 for predicting the prognosis of ACI was 0.830 and 0.882,The AUC of combined were 0.927.CONCLUSION Serum Neu5Ac and S100A1 levels increased in cases with ACI,and their changes were closely related to the condition and prognosis,and the combination had higher clinical efficacy in predicting prognosis of the disease.
acute cerebral infarctionN-acetylneuramic acidS100 calcium-binding protein A1prognosis
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