Application value of immature platelet fraction and glycocalicin index in cirrhosis-related thrombocytopenia
OBJECTIVE To explore the clinical significance of immature platelet fraction(IPF)and glycocalicin index(GCI)in the assessment of cirrhosis-related thrombocytopenia(TP).METHODS A total of 83 patients with hepatitis B cirrhosis-related TP admitted from April 2020 to December 2021 were included in the case group,their clinical data were retrospectively analyzed,TP was diagnosed and graded according to guidelines.In the same period,30 healthy subjects matched in age and sex were included in the control group.The severity of cirrhosis was judged by MELD score and Child-Pugh grading.Serum GC levels were measured by ELISA and GCI was calculated.Blood cell analyzer was used to output parameters IPF.The correlation of IPF and GCI with cirrhosis severity and TP grade was analyzed.RESULTS Compared with the control group,IPF and GCI were significantly higher in patients with cirrhosis in the case group(P＜0.001),while GC concentration was significantly lower(P=0.002).The IPF and GCI were significantly different among the TP grade groups(P=0.010,P＜0.001),and GCI increased with the increase of Child-Pugh grading(P=0.013).Spearman correlation analysis showed that GCI was significantly positively correlated with MELD score of liver disease severity(r=0.310,P=0.004),and HBV-DNA load(r=0.222,P=0.044).CONCLUSIONS IPF and GCI are associated with the severity of cirrhosis and TP grade and can be used to assess disease progression.
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