Clinical value of combined detection of Adenosine deaminase,5'-nucleotidase,and glutathione reductase in the evaluation of liver injury in patients with hepatitis B
OBJECTIVE To explore the clinical value of combined detection of Adenosine deaminase(ADA),5'-nucleotidase(5'-NT),and glutathione reductase(GR)in the evaluation of liver injury in patients with chronic hepatitis B(CHB).METHODS A total of 72 patients with CHB treated from January 2020 to June 2024 were selected as the experimental group,and divided into mild group(n=39),moderate group(n=25)and severe group(n=8)according to different degrees of liver injury.Additionally,72 healthy individuals who underwent health examinations during the same period were selected as the control group.Blood samples of all subjects were collected,and serum ADA,5'-NT,and GR levels were detected and compared among all groups.RESULTS The serum levels of ADA,5'-NT,and GR in the experimental group were significantly higher than those in the control group(P＜0.05).The serum ADA,5'-NT,and GR levels in the severe group were significantly higher than those in the moderate and mild groups,and the serum ADA,5'-NT,and GR levels in the moderate group were significantly higher than those in the mild group,with statistical significance(P＜0.05).CONCLUSION The combined detection of serum ADA,5'-NT,and GR can be used in the clinical auxiliary diagnosis of CHB and the evaluation of the degree of liver injury,and provide a basis for formulation of clinical diagnosis and treatment plan.
hepatitis Bliver injuryadenosine deaminase5'-nucleotidaseglutathione reductase
NETL
NSTL
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