首页|艾滋病合并隐球菌脑膜炎患者CD4+、CD8+淋巴细胞计数变化及与预后的关系

艾滋病合并隐球菌脑膜炎患者CD4+、CD8+淋巴细胞计数变化及与预后的关系

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[目的]探讨艾滋病(AIDS)合并隐球菌脑膜炎患者外周血CD4+淋巴细胞计数、CD4+/CD8+比例变化及与预后的关系.[方法]选择自2019年1月至2023年5月间就诊于郑州市第六人民医院的AIDS合并隐球菌脑膜炎患者86例纳入研究组,并选择同时期30名体格检查健康者纳入对照组.采用流式细胞术检测两组外周血CD4+淋巴细胞及CD4+/CD8+比例,并进行比较;分析研究组患者预后情况.[结果]研究组外周血CD4+淋巴细胞计数及CD4+/CD8+比例均明显低于对照组(P<0.05);自患者入院至出院后3个月无失访情况,其中存活74例,死亡12例;死亡组外周血CD4+淋巴细胞计数<50个/μL、意识障碍占比、HIV RNA数、颅内压情况、存在其他合并症占比均明显高于生存组(P<0.05);意识障碍、低外周血CD4+计数、高HIVRNA、高颅内压、存在其他合并症均是影响AIDS合并隐球菌脑膜炎患者预后不良的危险因素(P<0.05).[结论]AIDS合并隐球菌脑膜炎患者CD4+淋巴细胞计数明显下降,低水平CD4+与患者预后不良有关.
Changes of CD4+and CD8+lymphoid count and their relationship with prognosis in acquired immuno deficiency syndnme patients combined with cryptococcal meningitis
OBJECTIVE To investigate the change of CD4+lymphocyte count and CD4+/CD8+ratio and its relationship with prognosis in peripheral blood of acquired immuno deficiency syndnme(AIDS)patients combined with cryptococcal meningitis.METHODS A total of 86 AIDS patients combined with cryptococcal meningitis admitted to the Sixth People's Hospital of Zhengzhou from January 2019 to May 2023 were included in the study group,and 30 healthy subjects were included in the control group at the same time.The levels of CD4+lymphocytes and the ratio of CD4+/CD8+in peripheral blood of the two groups were detected by flow cytometry and compared.The prognosis of patients in the study group was analyzed.RESULTS CD4+lymphocyte count,and the ratio of CD4+/CD8+in peripheral blood of the study group were significantly lower than those of the control group(P<0.05).From the time of admission to 3 months after discharge,there was no loss of follow-up cases.74 patients survived and 12 died.The count of CD4+lymphocytes in peripheral blood<50/μL,the proportion of consciousness disorder,the number of HIV RNA,intracranial pressure and other complications in the death group were significantly higher than those in the survival group(P<0.05).Disturbance of consciousness,low peripheral blood CD4+count,high HIV RNA,high intracranial pressure and other complications were all risk factors for poor prognosis in AIDS patients combined with cryptococcal meningitis(P<0.05).CONCLUSIONS CD4+lymphoid count decreased significantly in AIDS patients combined with cryptococcal meningitis.Low levels of CD4+were associated with poor prognosis.

acquired immuno deficiency syndnmecryptococcal meningitisCD4+CD8+prognosis

崔美灵、刘春礼、张焕霞、仝小庆

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郑州市第六人民医院感染科,河南郑州 450000

艾滋病 隐球菌脑膜炎 CD4+ CD8+ 预后

2024

延边大学医学学报
延边大学

延边大学医学学报

影响因子:0.308
ISSN:1000-1824
年,卷(期):2024.47(2)