Analysis of risk factors and immune function changes in patients with non-small cell lung cancer complicated with Toxoplasma gondii infection
Objective To study the risk factors and immune function changes in patients with non-small cell lung cancer(NSCLC)complicated with Toxoplasma gondii infection.Method A total of 283 NSCLC patients admitted to Hefei Cancer Hospital of Chinese Academy of Sciences from March 2021 to October 2023 were selected and divided into infected group(n=26)and non-infected group(n=257)according to the infection status of Toxoplasma gondii.The baseline data,laboratory indicators and humoral immune function indicators of the two groups were compared,and the risk factors of Toxoplasma gondii infection in NSCLC patients were determined by multivariate Logistic regression analysis.Result Age≥60 years old,raising cats and dogs at home,and prealbumin(PA)≤250 mg/L were risk factors for Toxoplasma gondii infection in NSCLC patients(all P<0.05).The levels of immunoglobulin A(IgA)and complement C4 in the infected group were higher than those in the non-infected group,and the levels of immunoglobulin G(IgG)were lower than those in the non-infected group(all P<0.05).Conclusion Age≥60 years old,raising cats and dogs at home,and PA≤250 mg/L are risk factors for Toxoplasma gondii infection in NSCLC patients.In addition,infection with Toxoplasma gondii can cause a significant decrease in humoral immune function,which should be given priority attention.
Non-small cell lung cancerToxoplasma gondii infectionRisk factorsImmune function
万方数据
维普
