Multifactor and correlation analysis of prostate health index and total prostate-specific antigen in the diagnosis of prostate cancer
OBJECTIVE To compare the impact of prostate health index(PHI)and total prostate-specific antigen(tPSA)on various clinical factors in the diagnosis of prostate cancer(PCa),and investigate the correlation between these factors and the above indicators,so as to provide evidence for clinicians in judging whether to do aspiration biopsy for suspected Pca patients.METHODS The preoperative examination data and pathological findings of 82 patients who underwent aspiration biopsy due to abnormal tPSA in the Affiliated Hospital of Yanbian University from March to December 2021 were collected.The data were divided into benign and malignant groups according to pathological results.The effects of prostate volume(PV),inflammation,bladder calculi,indwelling catheter and other factors on tPSA and PHI values were analyzed,and the sensitivity and specificity of tPSA and PHI in diagnosing Pca were further analyzed and compared.RESULTS There were significant differences in tPSA,PHI and PV between benign and malignant group(P<0.05).There was no statistical significance between indwelling catheter and urinary tract infection(P>0.05).There was a positive Spearman correlation between the presence and absence of catheter and tPSA(P<0.05),and no correlation with PHI(P>0.05).PV and pathological scores were positively correlated with Spearman correlation of tPSA and PHI(P<0.05).CONCLUSION The presence or absence of catheter and PV affect serum tPSA and PHI levels,in which PV is an independent factor affecting both,while the interference of PHI by catheter is less than that of tPSA.
prostate health indextotal prostate-specific antigenprostate cancercorrelation
万方数据
维普
