Analysis of the relationship between the content of vitamin D receptor and TREM-1 and gene polymorphisms and neonatal sepsis
Objective To explore and analyze the relationship between the content of vitamin D receptor and myeloid cell trigger receptor-1(TREM-l)and their gene polymorphisms and neonatal sepsis.Method A total of 100 newborns with sepsis who received treatment in Hohhot First Hospital from June 2021 to May 2023 were selected as the sepsis group,and 200 non-sepsis newborns were randomly selected as the non-sepsis group.The plasma TREM-l content,and the polymorphisms of vitamin D receptor gene and TREM-1 gene of the two groups were detected to analyze the factors leading to neonatal sepsis.Result The plasma levels of vitamin D receptor and TREM-1 content in the sepsis group were lower than those in the non-sepsis group(P＜0.05).The proportion of vitamin D receptor gene rs8848223 CC genotype and TREM-1 gene rs4711668 CC genotype in the sepsis group were higher than those in the non-sepsis group(P＜0.05),and the frequency of vitamin D receptor and TREM-1 gene C in the sepsis group were also higher than those in the non-sepsis group(P＜0.05).Binary Logistic regression analysis showed the vitamin D receptor gene rs8848223 CC genotype,TREM-1 gene rs4711668 CC genotype,rs8848223 allele C,and TREM-1 gene rs4711668 allele C,plasma levels of vitamin D receptors and TREM-1 were the factors leading to neonatal sepsis(P＜0.05).Conclusion Neonatal sepsis is often accompanied by decreased plasma vitamin D receptor and TREM-1 content,as well as vitamin D receptor and TREM-1 gene polymorphisms.Vitamin D receptor gene rs8848223 CC genotype and TREM-1 gene rs4711668 CC genotype,rs8848223 allele C,rs4711668 allele C,plasma levels of vitamin D receptors and TREM-1 are the factors leading to neonatal sepsis.
newbornsepsisvitamin D receptormyeloid cell triggered receptor-1influence factor
万方数据
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