Efficacy and safety of insulin glargine combined with metformin hydrochloride and acarbose in the treatment of type 2 diabetes
Objective:To explore the clinical effect of insulin glargine combined with metformin hydrochloride and acarbose in the treatment of type 2 diabetes.Methods:100 patients with type 2 diabetes who were admitted to Qidong Maternal and Child Health Hospital from March 2023 to March 2024 were included in the study,and they were randomly divided into two groups.The control group(50 cases)was treated with metformin hydrochloride combined with acarbose.The study group(50 cases)was treated with a combination of insulin glargine,metformin hydrochloride,and acarbose.The therapeutic effect of the two groups was compared.Results:After treatment,the total effective rate and islet β cell function index(HOMA-β)of the study group were significantly higher than those of the control group(P<0.05).The levels of fasting blood glucose(FBG),2-hour postprandial blood glucose(2 hPBG),glycated hemoglobin(HbAlc),and insulin resistance index(HOMA-IR)in the study group were significantly lower than those in the control group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups of patients(P>0.05).Conclusion:Insulin glargine combined with metformin hydrochloride and acarbose works better in the treatment of type 2 diabetes.
Type 2 diabetesInsulin glargineMetformin hydrochlorideAcarbose
万方数据
维普
