Objective: This paper examines the operation room nursing teaching, how to use graphic combination method and its effect. Methods: using the method of random digits table will be in 2013 March to 2013 December, in the operation room in the 363 Hospital of Chengdu 100 college nursing students were divided into observation group and control group each 50, observation group uses graphic combination method, the control group used the traditional teaching method. Results: the group of the overall theoretical results and operation results were significantly higher than those in control group. Conclusion: nursing teaching in operation room, combined with the ability of nursing students between theory and practice and the actual operation ability are better than the traditional teaching method was used to get the effect, is worthy of application and promotion.