Objective: Discussion on the safety analysis in newborn baby guardianship room and prevention countermeasures Methods:Through the comparison of 1002 cases with disease babys in newborn baby guardianship room from 2008 January to 2009 December and 1026 cases with disease babys in newborn baby guardianship room from 2010 January to 2011 December, It is Com-pared with the traditional safety management and the suspension safety warning labels predictive risk management. Results: Compared two groups of patients by fal ing out of bed, aspiration, scald, tube, switches, premature apnea and infected data analysis, In addition to being "stuff" no statistical difference, the rest of the difference between the two groups had statistical significance (P<0.05).