摘要
目的：比较结核感染T细胞斑点试验（T- SPOT. TB）和结核抗体试验（TB- Ab）在疑似结核患者诊断中的敏感性和特异性，探讨两者在结核感染中的诊断价值。方法：对疑似结核的74例患者进行前瞻性研究，分别采用T- SPOT. TB和TB- Ab试验，比较二者对结核诊断的敏感性、特异性、阳性预测值（PPV）、阴性预测值（NPV）、阳性似然比（LR+）和阴性似然比（LR-）。结果：74例疑似结核患者确诊结核52例。T- SPOT. TB试验在敏感性、特异性、PPV、NPV等方面显著优于TB- Ab （P<0.05）；T- SPOT. TB的LR+值明显高于TB- Ab，LR-值明显低于TB- Ab。结论：T- SPOT. TB试验是诊断结核的快速敏感方法，显著优于结核抗体试验（TB- Ab），更适于作为结核筛检试验，在结核疾病诊断中有着重要价值。
Abstract
Objective To compare the sensitivity and specificity in diagnosis of tubeiculosis by T- SPOT. TB to TB- Ab, in order to discuss their diagnosis values. Method 74 patients suspected to be infected with tuberculosis were taken into study. They were indi-vidually tested by T- SPOT. TB and TB- Ab. When their diagnosis were certain, the sensitivity, specificity, positive prospective value, negative prospective value, positive likelihood ratio and negative likelihood ratio of the two different diagnosis method were calculated. Result Ultimately 52 patients were confirmed to have tuberculosis infected. The T- SPOT. TB showed obvious advantages in sensitivi-ty, specificity, positive prospective value, negative prospective value, positive likelihood ratio and negative likelihood ratio compared to TB- Ab. Conclusion The T- SPOT. TB is a faster and more sensitive method in the diagnosis of tuberculosis compared to TB- Ab.
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