Objective:Study of thermo- responsive nanopore used indrug delivery. Method:Polycarbonate membranes were func-tionally modified with PNIPAm, and then the properties of these functional temperature responsive membranes were investigated . Re-sults:the Diameter of the nanochannels decreased at 25℃and increased at 37℃, and the nanopores can be used to control the drug de-livery at different rate.