Objective: To investigate the clinical efficacy of the new treatment Deanxit refractory gastroesophageal reflux disease. Methods:Hospital diagnosed 168 cases of patients with gastroesophageal reflux disease, according to a completely random way divided into two groups, the control group was given Mosapride and esomeprazole for treatment, observation group basis in the control group on the use of deanxit treatment, clinical symptoms in the two groups of patients, psychological status and treatment efficiency. Results:After treatment with a mood disorder total scores contrast significant difference was statistically significant (P<0.05). The control group was 90.48%effective in the treatment group was 64.29%, of which the difference was statistically significant (P<0.05). Conclusions:In the treatment of refractory gastroesophageal reflux disease plus Deanxit have good clinical results, worthy of promotion in clinical prac-tice.