objective to study the immune regulator treatment effect of children's multiple verruca vulgaris. Method the research ob-ject for the September 2012 to September 2013 dermatology clinics receiving treatment of 58 cases of children with multiple verruca vulgaris, observation group (29 cases) treated with immune regulator, the control group (29 cases) treated with gamma interferon, after treatment with different drugs for clinical curative effect of the comparison. Results observation group treatment the total effective rate was 89.66%, the adverse reaction rate was 10.34%; The control group total effective rate was 55.17%, the adverse reaction rate was 27.59%. Comparison between groupχsquared=30.56, 10.47, statistics has obvious difference. Conclusion of immune modulators in the treatment of children's multiple verruca vulgaris is better than gamma interferon, at the same time, low incidence of adverse reactions,high security, high value of clinical use.