objective to analyze anhui area children allergens IgE test results, understand allergens and the relationship between aller-gic disease, and the distribution characteristics of local allergens. Methods use Al ergy Screen kit, using western blot method, 315 children with anhui region detection of serum IgE allergens, and the results of the analysis. Results 185 cases of a total of 315 cases of children IgE al ergens positive, positive rate was 58.73%. Inhaled allergies, a total of 108 cases (58.38%), eating sex allergy, a total of 77 cases (41.62%),P<0.05, the difference was statistically significant. Eat most allergens of urticaria, positive rate was 23.38%. Inhaled allergens of allergic rhinitis, most positive rate was 29.63%. Inhaled allergens in the cat hair, dog epithelium, house dust, dust mites are the main combination inhalation allergen, the positive rate of 31.48%, 25.00%, 31.48%and 25.00%respectively. Eat seafood al ergens in combination, combi-nation of freshwater fish, milk is the main food allergen in the sex, the positive rate of 25.97%, 20.78%and 14.29%respectively. Con-clusion there are many different kinds of allergens in children and inhaled allergens positive rate is relatively high food allergen in the sex. The allergen detection helps children allergic disease diagnosis and prevention.