Objective:Analysis the variation of red blood cell distribution of colonic perforation with septic shockMethods:Total of 50 patients withseptic shock of colonic perforation admitted from November 2013 to October 2014 were retrospectively.APACHEⅡscore,PCT and RDW at the beginning of and 24 hours after shock,as well as the outcome of Day 60 after the diagnosis were recorded. Analysis of indicators.Results:RDW,APACHE Ⅱscore,PCT and age were higher in non- survivors than those in survivors;the logistic analysis showed thatAPACHE Ⅱscore and RDW was the risk factors for death. Conclusion:RDWof the patients with septic shock of colonic perforationis a robust predictor of mortality.RDW may be another important indicator of prognosis in patients with septic shock judgment.