objective:to comparison and analysis of laparoscopic minimally invasive surgery and open operation curative effect for the treatment of gallbladder calculi and cholecystitis. Methods:from January 2011 to April 2013 our application between micro ChuangShu laparoscopic treatment of 71 patients with gal stones and cholecystitis as experimental group, in our hospital from January 2009 to De-cember 2010 application fiber choledochoscope joint line B ultrasonic open surgical treatment of 63 cases as control group, compared two groups of patients with curative effect. Results:after treatment, the treatment group patients with operation time, surgical blood loss and the total length of hospital stay were significantly better than the control group, the total effective rate was significantly higher than that of control group, led traffic significantly less than the control group, two groups of data by comparing differences statistically signifi-cant, (P<0.01). Conclusion:laparoscopic micro ChuangShu applied in gallstones and cholecystitis in curative effect good, small patients with trauma, rapid recovery, popularization and application value.