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小承气汤与厚朴三物汤的药理作用分析和临床研究

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目的:探讨小承气汤与厚朴三物汤的药理作用分析和临床研究。方法:以健康的大鼠作为研究对象,体重约250g左右,雌雄不限,共100只,按随机数字表法将100只小鼠分成4组,每组25只,定义为A组、B组、C组、D组。选取A组、B组并禁食12小时,然后给予复方地芬诺酯10mg/kg,在服用后2小时制备成便秘模型。然后对A组、B组大鼠进行喂服含有墨汁染黑的小承气汤(2g/kg)或厚朴三物汤(2g/kg),并添加正常大鼠食料与纯净水。观察A组、B组大鼠首次黑便排出时间及6小时内黑便排出点数。对C组、D组大鼠服用0.015%氨水5ml,在服用后立即给予服用小承气汤(2g/kg)或厚朴三物汤(2g/kg)。观察C组、D组大鼠咳嗽潜伏期及咳嗽次数。结果:A组与B组首次排便时间、6小时内黑便排出点数分别为(122.7±32.4分钟、5.9±2.4点)、(74.5±52.3分钟、3.4±2.7点),差异有统计学意义(P<0.05);C组、D组大鼠咳嗽潜伏期及咳嗽次数分别为(85.8±12.7秒、62.4±12.9次)、(96.5±10.5秒、56.9±13.5次),差异有统计学意义(P<0.05)。结论:本次研究认为小承气汤泻下作用强,厚朴三物汤止咳作用明显。
To investigate the clinical study of smal Dachengqitang and Magnolia three things soup analysis and pharmacological ef-fects. Methods:healthy rats as subjects, weighing about 250g or so, male or female, a total of 100, according to a random number table 100 mice were divided into four groups, each 25, defined as group A and group B group C, D groups. A select group B and fasted for 12 hours, then give compound diphenoxylate 10mg/kg, in the two hours after taking the model prepared constipation. Then the group A and group B rats were fed ink to black suits contain small Dachengqitang (2g/kg) or Magnolia officinalis three Wu- Tang (2g/kg), and add the normal rats diets with pure water. Observed in group A and B will be discharged black rats first time and will be discharged within six hours of black dots. For group C, D group were administered 0.015% ammonia 5ml, given after taking taking small Dachengqitang (2g/kg) or Magnolia officinalis three Wu- Tang (2g/kg) immediately. Observation group C, D group were cough cough latency and number. The results:A group and B group first defecation time will be discharged within six hours of black dots, re-spectively (122.7 ± 32.4分钟, 5.9 ± 2.4 points), (74.5 ± 52.3分钟, 3.4 ± 2.7 points), the difference was statistically significant (P<0.05);group C, group D rats cough cough latency and the number was (85.8 ± 12.7秒, 62.4 ± 12.9 times), (96.5 ± 10.5秒, 56.9 ± 13.5 times), the difference was statistically significant (P<0.05). Conclusion:This study suggests that small Dachengqitang strong lax-ative effect, Magnolia three things soup cough effect is obvious.

smal DachengqitangHoupu three things soupdiarrheacough

伍丽雄

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湖南省邵阳市中心医院 422000

小承气汤 厚朴三物汤 泻下 止咳

2015

延边医学

延边医学

ISSN:
年,卷(期):2015.(7)
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