Objective:To explore the nursing intervention measures analysis of biliary fistula after operation of liver and gall. Meth-ods: select 90 cases of biliary fistula in our hospital from 2012 October to hepatobiliary surgery in 2014 October after treated patients were randomly divided into observation group and control group, each of 45 cases. The patients in the observation group were given comprehensive nursing intervention, control group received routine nursing intervention group patients. The time of hospitalization time, drainage nursing satisfaction were observed in the two groups of patients with preoperative and postoperative. Results:observation and nursing satisfaction were 97.8%, the control group of nursing satisfaction of patients was 73.3%, the difference of the two groups was significantly (P<0.05), with statistical significance; time, hospitalization time were less than that in the control group the observation group patients after drainage, the difference of the two groups significantly (P<0.05), with statistical significance. Conclusion:the imple-mentation of comprehensive nursing intervention on the occurrence of biliary fistula after hepatobiliary surgery patients, can effectively improve the patients' satisfaction to nursing care, reduce the pain of patients, it is worth popularizing and applying nursing measures.