目的：：目前化疗，手术和放疗是治疗恶性肿瘤的三大主要方法。然而，作为主要方法之一的化学疗法，在疗效方面一直不尽如人意，其中最主要的原因就是肿瘤细胞对药物产生了耐药性。肿瘤细胞对多种化疗药物产生交叉耐药性,即多药耐药(multiple drug resistance, MDR)[1]。MicroRNAs(miRNAs)在调节基因的表达与肿瘤细胞的表型方面已经发展成为一支重要力量，其与细胞的增值[2~4]，细胞周期进程[5~7]，侵袭[8~10]，以及分化[1,12]密切相关。同时, miRNA可以调控药物在体内的代谢,在肿瘤细胞对抗癌药物产生耐药方面发挥了重要作用[13]。故本文对miRNA与肿瘤多要耐药的关系及研究进展做一综述。
Objective At present, chemotherapy、operation and radiotherapy are the three main methods for the treatment of malig-nant tumors. However, as one of the main methods of chemical therapy, it always have poor response to treatment, which is the main reason is multiple drug resistance. MicroRNAs in the regulation of gene expression and phenotype of tumor cells has become an impor-tant strength, it is associated with the cell proliferation, cell cycle progression and invasion. At the same time, miRNA can regulate the drug metabolism in vivo, it also play an important role in develop resistance to anticancer drugs. The authors review the advances in the miRNAs and multidrug resistance of tumor.
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