首页|AEC-Ⅱ凋亡中microRNA表达的研究进展The Progress of AEC-Ⅱapoptosis in microRNA expression in hyperoxia-induced Iung injury
AEC-Ⅱ凋亡中microRNA表达的研究进展The Progress of AEC-Ⅱapoptosis in microRNA expression in hyperoxia-induced Iung injury
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随着医疗技术的发展，呼吸机辅助呼吸技术运用十分广泛，利用其治疗各种诱因引起低氧血症效果显著，AEC-Ⅱ细胞容易受到空气和血液的损害，机械通气时气道压力变化、氧气浓度的变化以及肺泡的被动运动均可以直接造成AEC-Ⅱ功能损伤和形态变化。长时间吸入高氧浓度可引起AEC-Ⅱ凋亡，导致新生儿支气管肺发育不良、成人急性呼吸窘迫综合症（ARDS）等，近年来国内外研究发现高氧肺损伤致AEC-Ⅱ凋亡过程中，伴有微小RNA（microRNA or miRNA）表达谱的明显改变，现对高氧肺损伤致AEC-Ⅱ凋亡中mircoRNA表达的研究进展进行综述。
With the development of medical technology, ventilator- assisted breathing techniques to use a very wide range, with its treatment of a variety of incentives to cause hypoxemia significant effect, AEC- Ⅱ cells susceptible to air and blood damage, airway pressure changes during mechanical ventilation, changes in oxygen concentration and alveolar passive movement can cause AEC- Ⅱfunctional impairment and morphological changes directly. Prolonged inhalation of high concentrations of oxygen can cause AEC- Ⅱapoptosis, resulting in neonatal bronchopulmonary dysplasia, adult acute respiratory distress syndrome (ARDS), etc., at home and abroad in recent years, studies have found hyperoxia- induced lung injury induced apoptosis of AEC- Ⅱin, accompanied by smal RNA (mi-croRNA or miRNA) expression was significantly changed spectrum, is to hyperoxia- induced lung injury progress AEC- Ⅱexpression induced apoptosis mircoRNA reviewed.
hyperoxia- induced lung injurytypeⅡalveolar epithelial cell or typeⅡpneumocyte,ATⅡapoptosismiRNA
何英、程云、石磊、陈淼
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遵义医学院 贵州遵义 563003
高氧肺损伤 肺泡Ⅱ型上皮细胞(typeⅡalveolar epithelial cell or typeⅡpneumocyte,ATⅡ) 凋亡 miRNA
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