摘要
目的：：观察乌司他丁对脓毒性脑病患者血清TNF-α、IL-1及S-100蛋白浓度变化的影响。方法：将60例脓毒性脑病患者，随机分为治疗组(28例)和对照组(32例)，对照组给予常规治疗，治疗组加用乌司他丁，分别观察两组的疗效及TNF-α、IL-1及S-100蛋白浓度变化。结果：与对照组相比，治疗组第3、5天的血清TNF-α，IL-1，及S-100蛋白浓度血清较对照组显著降低，差异具有统计学意义（P＜0．05）；且机械通气时间和住ICU时间较对照组缩短，差异有统计学意义P＜0．05。结论：乌司他丁可降低血清TNF-α，IL-1，及S-100蛋白浓度，治疗脓毒性脑病疗效显著。
Abstract
Objective To observe the effects of ulinastatin on serum contents of TNF- α、IL- 1 and S- 100 protein in patients with septic encephalopathy. Methods Sixty adult patients were divided into the treatment group (n=28) and the control group(n=32)?ran-domly.The control group was given conventional treatment, and ulinastatin was only administrated to the treatment group. Serum con-tents of TNF- α, IL- 1 and S- 100 protein were measured and recorded and observation of the therapeutic effect of two groups of pa-tients. Results Compared with the control group, treatment group third and 5 days of serum TNF- , IL- 1, and S- 100 protein concen-tration in serum was significantly decreased compared with the control group, with significant difference (P<0.05);and the time of me-chanical ventilation and ICU stay time was shorter than the control group, there were statistically significant differences in P < 0.05. Conclusion Ulinastatin can reduction of serum TNF- , IL- 1, and S- 100 protein concentration,and the therapeutic effect is obviously.
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