Objective To observe the effects of ulinastatin on serum contents of TNF- α、IL- 1 and S- 100 protein in patients with septic encephalopathy. Methods Sixty adult patients were divided into the treatment group (n=28) and the control group(n=32)?ran-domly.The control group was given conventional treatment, and ulinastatin was only administrated to the treatment group. Serum con-tents of TNF- α, IL- 1 and S- 100 protein were measured and recorded and observation of the therapeutic effect of two groups of pa-tients. Results Compared with the control group, treatment group third and 5 days of serum TNF- , IL- 1, and S- 100 protein concen-tration in serum was significantly decreased compared with the control group, with significant difference (P<0.05);and the time of me-chanical ventilation and ICU stay time was shorter than the control group, there were statistically significant differences in P < 0.05. Conclusion Ulinastatin can reduction of serum TNF- , IL- 1, and S- 100 protein concentration,and the therapeutic effect is obviously.
septic encephalopathyulinastatinInflammatory factorS- 100 protein
NETL
NSTL
万方数据
