Objective To study the effect of ginseng extract Rb1 component on hypertrophic scars, providing a new method for the treatment of hypertrophic scars. Methods Select a very mature hypertrophic scar model rabbit ears, do three in each ear hypertrophic scars, scars do each different treatment:control group (a), saline injection group (b), ginseng extract (c). To subject the Masson staining, collagen determination and chemical related expression of immunohistochemistry protein col agen type 1 in each group. Results The Masson staining, collagen determination and chemical related expression of immunohistochemistry protein collagen type 1 in Rb1 group were lower than the other groups. Conclusion The Rb1 can inhibit the development of hypertrophic scars.