objective:to analysis the clinical curative effect of ulinastatin treatment of acute pancreatitis. Selection methods:clinical data of 60 patients admitted in our hospital with acute pancreatitis, randomly divided into treatment group and control group, 30 cases each. , control group treated with conventional treatment group implementation of ulinastatin treatment, compared two groups of pa-tients with clinical efficacy. Results:treatment group total effective rate of 93.33%is significantly higher than the control group 76.67%, the difference was statistically significant (P<0.05). Treatment group abdominal pain relief time, pancreatic edema disappeared, active for the first time defecation time were significantly shorter than the control group, the difference was statistically significant (P<0.05). CRP, TNF- a group after treatment, IL- 15, IL- 10 levels significantly lower than the control group, the difference was statistically significant (P<0.05). CRP, TNF- a group after treatment, IL- 15, IL- 10 levels significantly lower than the control group, the dif-ference was statistically significant (P< 0.05). The incidence of adverse reactions was 6.67% treatment group was obviously less than 20.00%in the control group, the difference was statistically significant (P<0.05). Conclusion:ulinastatin treatment of acute pancreatitis, curative effect of safety, fully improve the inflammatory factor levels, effective control of the disease, reduce the incidence of adverse re-actions, worthy of clinical promotion.