摘要
目的：：观察右美托咪定在开腹肝脏肿瘤切除手术患者全身麻醉中的有效性和安全性。方法：择期开腹肝脏肿瘤切除手术患者60例，年龄30～65岁，ASAⅠ～Ⅲ级，随机均分为两组，麻醉诱导和维持分别采用丙泊酚（P组）和右美托咪定（D组），同时均吸入七氟烷。观察和记录麻醉期间患者MAP和HR的变化，苏醒时间和术毕时出现的烦躁、瞻望等不良反应情况。结果：与麻醉前比较，P组MAP在气管插管前显著降低，气管插管后和拔管前显著升高（P＜0.05），D组MAP未有显著变化，麻醉诱导后D组HR明显减慢（P＜0.05），P组HR仅在气管插管后和拔管前显著增快（P＜0.05）,P组术毕2例患者出现术后躁动，D组未见明显不良反应。结论：右美托咪定用于开腹肝脏肿瘤切除手术患者，心率减慢，血压稳定，苏醒及时，术后躁动等不良反应少。
Abstract
Objective To observe the effects of dexmedetomidine efficacy and safety in open liver tumorresection operation in pa-tientswith generalanesthesia. Methods elective abdominal operation patients with liver tumorresectionin60 cases, age 30 ~65 years old, ASAI ~ IIIgrade, wererandomlydividedintotwo groups, anesthesia wasinducedandmaintained with propofolrespectively (groupP) and dexmedetomidine (groupD), andallofthemwereinhaled seven sevoflurane. Changesin MAPandHR patientsduring theobservationan-drecordingofanesthesia,adversereactions andirritability, andothercircumstances ofrecoverytimeand look attheendoftheoperation.Results compared with those beforeanesthesia, P group, MAP decreased significantly before tracheal intubation, after tracheal intubation and ex-tubationwere significantly higher (P<0.05), significant changes in group D MAP no, after induction of anesthesia in group D HR is significantly slower (P<0.05), P groupHR only after intubation andextubation before significantlyfaster (P<0.05),restless P groupafter-operation 2patients afteroperation,Dgrouphadnoobviousadversereaction.Conclusiondexmedetomidine for open liver tumorresection pa-tients, heartrate, bloodpressure stable, wakeup intime,postoperative agitation and other less adverse reaction.
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