Objective To find out the current situation of the cleaning effect of medical instrument, promote and improve the cleaning quality. Methods Using the method of combination of check and sampling detection, tracking survey of Wei fang city under the jurisdiction of 16 medical institutions the quality of cleaning, cleaning the regional layout, cleaning equipment is perfect, central sup-ply problems, washing procedure. Results 65% of the hospitals have no clear improvement, cleaning equipment lack, cleaning site mixed, the unified central supply has not implemented;75%of the two level of hospital equipment cleaning quality qualified rate in-crease;three hospital cleaning quality qualified rate remained 100%. Conclusion The quality of cleaning a hospital and part of the two level of hospital is still a problem, proposed the establishment of regional supply center, in order to improve the cleaning quality qualified rate.