Objective:This paper examines the application of graphic combination method in the operation room nurse teaching and the effect of this method. Methods:100 college nurse students were divided into observation group and comparing group each 50,with the method of random digits table,in the operation room of the 363 Hospital of Chengdu from 2013 March to 2013 December.The ob-servation group students were teached with graphic combination method, and the comparing group students were teached with the tra-ditional method. Results:The thoretical result and the operation result of observation group were significantly higher than those in the comparing group. Conclusion: The teaching effect of the graphic combination method is better than the traditional teaching method.And this method is worth of application and promotion in the operation room nurse teaching.