Objective: To investigate the clinical effect of thrombolytic therapy in patients with cardiopulmonary resuscitation. Methods:80 cases of cardiopulmonary resuscitation in patients with relevant information in our hospital to undertake a comprehensive retrospective analysis, based on patients with different treatment options will be divided into a control group and the experimental group and the control group, the implementation of conventional therapy, the implementation of thrombolytic therapy in the experimental group, therapeutic effects were compared.Results:The experimental group restoration of spontaneous circulation was 90%, 24h survival rate was 60%, 13 cases recovered and were discharged after treatment, neurological recovery rate was 47.5%, higher than the control (P<0.05);two groups of patients before treatment serum related indicators were no significant differences (P>0.05);experimental group therapy AST indicators (65.2 ± 14.7), LDH index is (227 ± 16.8), CK indicators (418.8 ± 34.6), CK- MB indicators (88.1 ± 14.8), were lower than in the control group (P<0.05).Conclusions:Most patients with cardiac arrest caused by acute myocardial infarction, treatment of patients with thrombolytic therapy using the results are satisfactory, can improve the clinical efficacy and should be intro-duced.