肿瘤转移休眠与雌激素受体阳性乳腺癌关系的研究进展
杨东 1姜浩 1祖旭宇1
作者信息
- 1. 湖南省南华大学附属第一医院 421001
- 折叠
摘要
乳腺癌是女性最常见的恶性肿瘤之一，是全球女性癌症死亡的主要原因之一。几乎所有的乳腺癌相关性死亡都是由于癌症转移而不是原位肿瘤引起。其中大约20%-40%的乳腺癌患者会在确诊几年甚至几十年后发生远处转移，这一现象在雌激素受体阳性（estrogenreceptor positive，ER＋）乳腺癌中尤为多见。这表明，在经过一系列辅助治疗后，ER＋癌细胞或许依旧保持长时间休眠状态。在此，我们回顾了ER＋乳腺癌转移休眠的临床表现，介绍了目前用于肿瘤休眠生物学研究的多种实验模型、转移休眠的潜在机制，讨论了关于预防、检测和治疗休眠转移的各种临床挑战，并提出了关于ER＋乳腺癌转移休眠未来的研究方向，为进一步改善乳腺癌患者预后做出贡献。
Abstract
Breast Cancer is one of the most maligant tumors in female,and it is a major cause of cancer death in women worldwide.About 20%-40% patients would have invasion and metastatic spreading after their?diagnosis in a few years or even decades later.This phenomenon is more obvious in ER+(estrogen receptor positive) Breast Cancer,suggesting that ER+ Breast Cancer cells may keep a dormant stage in a long time after a series of adjuvant therapy.This review is focus on the clinical?features of the tumor dormancy in ER+ Breast Cancer cells and many kinds of experimental models that currently used in the biological studies of tumor’s metastasis dormancy.We also discuss the clinical challenges of prevention,detection and treatment about the metastasis dormancy in ER+ Breast Cancer cells,and put forward the research direction to contribute to further improve the prognosis of breast cancer patients .
关键词
雌激素受体阳性/转移休眠/乳腺癌Key words
ER+/Metastasis Dormancy/Breast Cancer Keywords:ER+/Breast Cancer引用本文复制引用
出版年
2015
NETL
NSTL
万方数据